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由供者提供的EB病毒(EBV)特异性的细胞毒T淋巴细胞(C:17lJ)能够成功地预防和治疗接受同种骨髓移植者的EB相关性淋巴细胞增生症。这一发现提示我们运用类似的方法治疗复发的EB病毒阳性的霍奇金病患者,匕名霍奇金病患者中有11人在第一次或第二次治疗中产生了自身的EBV特异
Epstein-Barr virus (EBV)-specific cytotoxic T-lymphocytes (C: 17lJ) provided by donors were able to successfully prevent and treat EB-associated lymphoproliferative disease in patients receiving allogeneic bone marrow transplants. This finding prompted us to use a similar approach to treat patients with relapsed EBV-positive Hodgkin’s disease. Eleven of the patients with non-Hodgkin’s disease developed their own EBV specificity during the first or second treatment.