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恶性脑胶质瘤(星形细胞瘤Ⅲ、Ⅳ级、多形性胶质母细胞瘤)在癌瘤中最令人畏惧,盖因其自然病程从出现临床症状之日起直至死亡的平均时限不及6～7月.常规治疗(手术+放疗)后的平均存活期亦未逾一年.辅助性化疗的尝试在初期屡遭失败,此系由于已知的抗有丝分裂药物都不能通过血脑屏障之故.自从弥漫性制剂,主要是亚硝脲类(BCNU, CCNU)发现以来,才克服了上述障
Malignant gliomas (astrocytoma grades III and IV, glioblastoma multiforme) are the most feared cancers because of the natural timing of their natural course from the onset of clinical symptoms until death. Less than from June to July. The average survival time after conventional treatment (surgery + radiotherapy) was less than one year. Attempts to assist chemotherapy were repeatedly failed at the initial stage because none of the known anti-mitotic drugs could cross the blood-brain barrier. As a result, since the discovery of diffuse preparations, mainly nitrosurea (BCNU, CCNU), the above barriers have been overcome.