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目的探讨单服一种药物与循环给药法治疗老年肺结核的近期疗效。方法选择 96例活动性肺结核患者随机分为循环给药和常规给药组 ,两组均为 48例 ,观察分析治疗后的疗效和副作用。结果两种给药法在开始治疗 3个月后痰镜检细菌学阳性的阴转率均为10 0 % ,满疗程时胸部 X线检查总有效率分别为 91.9%和 88.9% ,两组比较无显著性差异 (P>0 .0 5 ) ,而两组治疗后副作用的发生率分别为 18.7%和 47.9% ,两组比较有显著性差异 (P<0 .0 1)。结论循环给药法在老年肺结核病治疗中是一种有效可行的方案 ,而且副作用轻 ,费用低 ,易于被患者接受
Objective To investigate the short-term curative effect of single-drug treatment and re-circulation therapy on senile pulmonary tuberculosis. Methods Ninety-six patients with active pulmonary tuberculosis were randomly divided into recycle administration and conventional administration groups, 48 cases in both groups. The curative effect and side effects after treatment were observed and analyzed. Results After 3 months of treatment, the negative conversion rates of bacteriology positive sputum microscopy were both 100%. The total effective rates of chest X-ray at the full course of treatment were 91.9% and 88.9% respectively. There was no significant difference (P> 0.05). The incidence of side effects after treatment in both groups were 18.7% and 47.9%, respectively, with significant difference between the two groups (P <0.01). Conclusion Cyclic drug delivery is an effective and feasible method in the treatment of pulmonary tuberculosis in the elderly, with mild side effects, low cost and easy acceptance by patients