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目的探讨乙型病毒性肝炎患者红细胞指标以及免疫功能变化及其临床意义。方法选取2012年2月至2014年3月深圳市南山区人民医院收治的乙型病毒性肝炎患者资料100例,对患者红细胞6项指标以及红细胞C3b受体花环形成率(RBC-C3b RR)、免疫复合物花环率(RBC-ICR)进行检测。结果在100例乙型病毒性肝炎患者中,重度慢性肝炎、肝硬化患者RBC、MCH、RDW、HCT、MCV、MCHC指标的异常率明均显高于体检健康者,差异均有统计学意义(均P<0.05);重度慢性肝炎、肝硬化患者RBC-C3b RR均明显低于体检健康者,RBC-ICR均明显高于体检健康者,差异均有统计学意义(均P<0.05)。结论乙型病毒性肝炎患者出现红细胞系统异常,免疫黏附功能明显改变,其指标的变化对临床防治具有重要意义。
Objective To investigate the changes of erythrocyte and immune function in patients with viral hepatitis B and its clinical significance. Methods A total of 100 patients with viral hepatitis B who were admitted to Nanshan District People’s Hospital of Shenzhen City from February 2012 to March 2014 were selected. Six indicators of erythrocyte and RBC-C3b RR, Immune complex rosette rate (RBC-ICR) were detected. Results The abnormal rate of RBC, MCH, RDW, HCT, MCV and MCHC in patients with severe chronic hepatitis and cirrhosis was significantly higher than that of healthy people in 100 cases of patients with hepatitis B (the difference was statistically significant ( (P <0.05). The RR of RBC-C3b in patients with severe chronic hepatitis and cirrhosis was significantly lower than that of healthy people (P <0.05). The RBC-ICR of patients with severe chronic hepatitis and cirrhosis was significantly higher than that of healthy people. Conclusion Hepatitis B patients with abnormal erythrocyte system, immune function significantly changed, and its changes in the index of clinical prevention and treatment is of great significance.