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心脏内含有阿片样肽及阿片受体,阿片受体的活动参与心脏调节。在离体灌流的心脏加入外源性阿片样肽,和缺血—再灌流的心脏一样,均可导致 cAMP 含量增加,并伴有心律失常。根据以上结果可推测:缺血—再灌流导致心脏内阿片样肽的释放增加,引起心脏 cAMP水平增高,激活钙通道而引致心律失常。一、心脏内的阿片样肽Hughes 等用小自鼠输精管生物检定法,首先在兔及大白鼠的心房提取物中发现心内源性阿片样肽。Weihe 等和 Lang 用高效液相色谱披术(HPLC),放射免疫法和大鼠输
The heart contains opioid peptide and opioid receptors, opioid receptor activity involved in cardiac regulation. The addition of exogenous opioid peptide to the perfused heart, like that of the ischemic-reperfused heart, can result in increased cAMP levels accompanied by arrhythmias. Based on the above results, it can be speculated that ischemia-reperfusion results in increased release of cardiac opioid peptide, increased cAMP levels in the heart, and activation of calcium channels, leading to arrhythmia. First, the heart of the opioid peptide Hughes and other small mouse vas deferens bioassay, first in the rabbit and rat atrial extract found in the cardio-endogenous opioid peptides. Weihe and Lang and other high-performance liquid chromatography (HPLC), radioimmunoassay and rat lose