PGE_2对CCI_4诱导的大鼠急性肝损害具有确切的细胞保护作用,能明显降低血清ASW、AST(-m)、ALT。减轻肝脏郁血水肿,降低肝细胞坏死、脂肪变性和炎症浸润等指标评分,并肯定了FGE_2的膜稳定效应,这可能是PGE_2对肝细胞保护效应的主要机制之一,还提出CCl_4对肝细胞膜性结构的损害呈均一性,FGE_2对肝细胞膜和线粒体都具有保护效应。 PGE2 has a definite cytoprotective effect on acute hepatic injury induced by CCI_4 in rats and can significantly reduce serum ASW, AST(-m), and ALT. Reduce liver edema, reduce liver cell necrosis, steatosis and inflammatory infiltration index scores, and affirmed the membrane stabilization effect of FGE2, which may be one of the main mechanisms of PGE2 on hepatocyte protection, also proposed CCl_4 on liver cell membrane The structural damage was homogeneous, and FGE 2 had a protective effect on hepatocyte membrane and mitochondria.