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维拉帕米(verapamil,异搏定)为一钙通道阻滞剂,临床已用于室上性心律失常、心绞痛、高血压与肥厚性心肌病的治疗。近年来,又发现下列几种新用途可供临床参考。防治偏头痛 偏头痛是由于去甲肾上腺素和5-HT等作用引起脑血管内径的改变。开始为强力的血管痉挛致缺血性神经原障碍和局限性神经损伤,继后又呈血管反射性扩张出现典型的波动性头痛。国外Herbert等研究表明维拉帕米可减少头痛频率、缩短头痛时间。其机制乃是维拉帕米作用于血管
Verapamil (verapamil) is a calcium channel blocker, which has been clinically used in the treatment of supraventricular arrhythmias, angina, hypertension and hypertrophic cardiomyopathy. In recent years, they also found the following new uses for clinical reference. Prevention and treatment of migraine Migraine is due to norepinephrine and 5-HT and other effects caused by changes in cerebral vascular diameter. Beginning as a strong vasospasm induced ischemic neuronal disorders and localized nerve damage, followed by vascular reflex dilation typical fluctuations in headache. Foreign Herbert and other studies have shown that verapamil can reduce the frequency of headache and shorten the duration of headache. The mechanism is that verapamil acts on blood vessels