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目的研究分析妊娠晚期孕妇血清总胆固醇和三酰甘油水平对妊娠结局的影响。方法选择2013年10月至2015年11月参加孕检的妊娠晚期单胎孕妇632例,通过对其分娩前1周进行血清总胆固醇和三酰甘油检测,比较不同血脂水平孕产妇妊娠结局的差异,并对血脂水平与妊娠合并症的关系进行分析。结果在妊娠晚期,多数孕妇均存在血脂不同程度的升高,以三酰甘油升高为主。三酰甘油水平大于正常值2倍时,孕产妇发生妊娠高血压综合征、产后出血以及胎膜早破的风险显著增加(P<0.05);而总胆固醇水平升高产妇发生妊娠期糖尿病、妊娠高血压综合征、肝内胆汁淤积症以及产后出血的风险增加(P<0.05)。结论在妊娠晚期较高水平的三酰甘油和胆固醇可引起多种妊娠相关疾病,增加不良妊娠结局的风险。加强妊娠晚期血脂水平监测并及时给予干预可有助于减少不良妊娠结局的发生。
Objective To study the effect of serum total cholesterol and triglyceride on pregnant outcome in the third trimester of pregnancy. Methods Six hundred and seventy pregnant women with singleton pregnancies participated in the pregnancy test from October 2013 to November 2015 were enrolled in this study. The serum total cholesterol and triglyceride levels were measured one week before delivery to compare the differences in pregnancy outcomes among different blood lipids , And the relationship between serum lipid and pregnancy complications were analyzed. Results in the third trimester of pregnancy, most pregnant women there are varying degrees of elevated blood lipids, triglyceride-based. The risk of pregnancy-induced hypertension, postpartum hemorrhage and premature rupture of membranes was significantly increased (P <0.05) when the level of triglyceride was more than 2 times of the normal value. However, the increase of total cholesterol level led to gestational diabetes mellitus and pregnancy Hypertension syndrome, intrahepatic cholestasis and increased risk of postpartum hemorrhage (P <0.05). Conclusions Higher levels of triacylglycerols and cholesterol in the third trimester can cause a variety of pregnancy-related illnesses and increase the risk of adverse pregnancy outcomes. Strengthening the monitoring of late pregnancy lipid levels and timely intervention can help reduce the incidence of adverse pregnancy outcomes.