利福平作为一线抗结核药物广泛应用于临床结核病的治疗,对细胞内、细胞外、酸性环境、碱性环境中的结核菌均有杀灭作用,易渗入组织及体液中,包括脑脊液,特别在脑膜炎时可达到有效治疗浓度,治愈了无数结核病患者。但其不良反应也给患者带来痛苦,甚至危及生命,给治疗工作带来困难。本文对利福平严重不良反应文献进行了复习,现总结如下。1不良反应1.1利福平致肺水肿王华钧等[1]报道:患者,男57岁。因 Rifampicin is widely used as first-line anti-TB drugs in the treatment of clinical TB. It has a killing effect on Mycobacterium tuberculosis in cells, extracellular, acidic environment and alkaline environment, and easily penetrates into tissues and body fluids, including cerebrospinal fluid In meningitis can achieve effective treatment concentration, cure countless tuberculosis patients. But its adverse reactions also bring pain to patients and even life-threatening, which brings difficulties to the treatment. This article reviewed the serious adverse reactions of rifampicin, are summarized as follows. 1 Adverse reactions 1.1 rifampic-induced pulmonary edema Wang Huajun et al [1] reported: The patient, male 57 years old. because