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目的 调查重型病毒性肝炎医院真菌感染 ,探讨提高治愈率的措施。方法 分析 3 7例重型病毒性肝炎医院深部真菌感染 ,其中 3 6例为慢性重型肝炎 ,血清胆红素 2 0 4～ 668/ 13 0～ 4 0 0 umol/ L ,凝血酶原活动度 7%～ 3 0 .1%。结果 病原菌以念珠菌为主 ( 77.2 % ) ,其次为酵母菌和曲霉菌。感染部位以下呼吸道为主 ( 5 2 .6% ) ,其次是口腔粘膜 ( 2 8.0 % )。病死率 64 .9%。结论 重型肝炎医院真菌感染的主要防治措施是积极改善肝功能、合理应用抗生素、早期诊治真菌感染。
Objective To investigate the prevalence of fungal infection in hospital with severe viral hepatitis and to explore ways to improve the cure rate. Methods Thirty-seven patients with severe viral hepatitis were analyzed for deep fungal infection. Among them, 36 were chronic severe hepatitis with serum bilirubin of 204 to 668/1300 to 400 umol / L and prothrombin activity of 7% ~ 3 0 .1%. Results The main pathogenic bacteria were Candida (77.2%), followed by yeast and Aspergillus. The main respiratory tract was below the infection site (52.6%), followed by oral mucosa (28.0%). The case fatality rate was 64.9%. Conclusion The main prevention and treatment measures for fungal infections in hospital with severe hepatitis are to improve liver function, make reasonable use of antibiotics and diagnose and treat fungal infections early.