INTRODUCTIONrnTotal joint arthroplasty is a common orthopedic surgical procedure with not only significant benefits but also challenging complications, especially related to infection.1 Prosthetic joint infection (PJI), which is an infection involving the implant and adjacent bone and joint tissues, affects up to 2％ of all primary arthroplasties, resulting in an estimated 25000 cases and costs exceeding $3.2 billion.2 The current standard of care therapy for chronic PJI of the hip and knee involves complete removal of all infected tissue and implants with eventual hardware replacement after prolonged antibiotic therapy. Successful treatment occurs in (65–90)％ of cases, but failure often requires further treatments, surgeries, or even amputation.3–4 As the total number of total hip and total knee arthroplasties in the United States is projected to exceed 4 million by the year 2030, these complications will only become more common.