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目的 了解缺氧对新生鼠脑细胞生物氧化的影响,寻找有效的干预治疗方法。方法 通过新生鼠缺氧模型测定脑细胞线粒体的最大呼吸速度(MRR)、呼吸控制比(RCR)及ATP合成量的变化,并观察脑蛋白水解物注射液的干预治疗作用。结果 缺氧使脑细胞生物氧化障碍,MRR、RCR降低,ATP合成量较对照组减少,干预治疗对代谢有一定改善作用。结论围生期缺氧干扰了脑细胞生物氧化功能,脑蛋白水解物注射液有助于脑细胞代谢。
Objective To understand the effect of hypoxia on the biological oxidation of brain cells in neonatal rats and to find out an effective intervention treatment. Methods The changes of maximal respiratory rate (MRR), respiratory control ratio (RCR) and ATP synthesis of brain mitochondria in neonatal rat hypoxia model were determined, and the effect of brain protein hydrolyzate injection was observed. Results Hypoxia blocked the biooxidation of brain cells, decreased MRR and RCR, and decreased the amount of ATP synthesis compared with the control group. The intervention therapy had some effects on the metabolism. Conclusions Perinatal hypoxia interfered with the biological oxidation of brain cells. Brain protein hydrolyzate injection was helpful to brain cell metabolism.