论文部分内容阅读
超抗原(superantigen,SAg)是一类能直接激活某些T细胞亚型或B细胞亚型的结构上相似的一类蛋白质,具有多种免疫活性,对SAg分子进行改造后,在肿瘤等疾病的免疫治疗中发挥重要作用且具有强大而广泛的免疫激活作用已越来越多引起人们的关注。树突状细胞(dendritic cell,DC)是已知体内功能最强的专职抗原提呈细胞,并被认为是体内惟一能活化静息T细胞的抗原递呈细胞,主要参与细胞免疫和T细胞依赖的体液免疫反应,在抗肿瘤免疫应答中起关键作用。本文就SAg和DC的抗肿瘤及其联合抗肿瘤作用做一综述。1 超抗原的抗肿瘤研究超抗原的免疫反应包括免疫激活、免疫抑制、免疫耐受和
Superantigen (SAg) is a type of structurally similar protein that directly activates certain T cell subtypes or B cell subtypes. It has multiple immunological activities. After SAg molecules are modified, Immunotherapy has played an important role and has a strong and extensive immune activation has been caused by more and more attention. Dendritic cells (DCs) are the most potent professional antigen-presenting cells in the body and are thought to be the only antigen presenting cells that can activate resting T cells in vivo. They are mainly involved in cellular immunity and T cell dependence Humoral immune response, plays a key role in the anti-tumor immune response. This article reviews the antitumor and antitumor effects of SAg and DC. Anti-tumor research of superantigens 1 The immune response of superantigens includes immune activation, immunosuppression, immune tolerance and