近30年来,角膜霉菌感染有所增加,虽有各种抗霉制剂治疗,但尚有不少病人未能治愈。这是由于尚未获得合适的治疗霉菌药物之故。1975年美国首先批准使用匹马霉素(natamycin或pimaricin),就因对眼内穿透性较差,仅对角膜浅层霉菌病有效,而对深层霉菌性角膜溃疡则无 The past 30 years, the corneal fungal infection has increased, although a variety of anti-fungal treatment, but there are still many patients failed to cure. This is due to the lack of proper treatment for mold medicine. In 1975, the United States first approved the use of natamycin or pimaricin, which was only effective on superficial mycotic mycosis due to poor penetrating ability in the eyes, but not to deep mycotic corneal ulcer