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用放射免疫法检测健康人30例及 MI(心肌梗塞)患者42例的血浆心钠素浓度,发现MI 患者明显高于正常人,尤以急性 MI 时显著。血浆心钠素水平在 MI 后3天达最高值,其后渐次回降,直至1个月仍维持较高水平。用γ心功能仪检测心功能,发现射血分数减低患者心钠素测值明显增高,而射血分数正常者上升幅度较小。作者认为 MI 病人的血浆心钠素浓度改变,可能与 MI 后心泵功能受损有关,检测血浆心钠素水平对 MI 患者的心功能估计或有一定意义。
Plasma atrial natriuretic peptide levels were measured by radioimmunoassay in 30 healthy subjects and 42 MI patients. It was found that MI patients were significantly higher than normal controls, especially in acute MI. Plasma atrial natriuretic peptide levels reached the highest level on the 3rd day after MI, and then dropped back gradually until a month later. Heart function test with γ heart function found that ejection fraction decreased atrial natriuretic peptide was significantly higher in patients with normal ejection fraction was smaller. The authors believe that MI patients with plasma concentrations of atrial natriuretic peptide changes may be related to cardiac dysfunction after MI related to the detection of plasma atrial natriuretic peptide in MI patients with cardiac function may be of some significance.