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酮康唑为咪唑类衍生物,具有较广谱的抗真菌作用,经研究证实,本品是一种睾丸合成的强力抑制剂,通过抑制细胞色素CP-450依赖酶系统起作用,随着临床的广泛应用,其新的用途也日益扩展,如用于高胆固醇血症,晚期前列腺癌、柯兴综合症、痤疮、鹅口疮、脑膜炎、黑热病等,现简介如下: 1、高胆固醇血症:李氏在应用酮康唑口服治疗7例晚期前列腺癌患者时发现,口服剂量800mg,每8h一次,治疗一周后胆固
Ketoconazole imidazole derivatives, has a broader spectrum of antifungal effect, confirmed by the study, this product is a potent inhibitor of testicular synthesis, by inhibiting the cytochrome CP-450 dependent enzyme system, with the clinical The new uses are also expanding, such as for hypercholesterolemia, advanced prostate cancer, Cushing’s syndrome, acne, thrush, meningitis, kala-azar, etc., are summarized as follows: 1, hypercholesterolemia : Lee’s application of ketoconazole oral treatment of 7 cases of advanced prostate cancer patients found that the oral dose of 800mg, once every 8h, after a week of treatment of gallbladder