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目的 探讨血清糖抗原50（CA50）检测在原发性肝癌诊断中的价值。 方法 采用IRMA方法检测38例原发性肝癌患者血清CA50水平，并与43例良性肝病及20例正常对照进行对比分析。 结果 肝癌患者血清CA50明显高于良性肝病组及正常对照组（Ｐ<0.05）。CA50诊断肝癌的敏感性为57.8%，与AFP联合检测诊断肝癌的敏感性可由单纯测定AFP的65.7%提高到89.4%。 结论 在原发性肝癌中，血清CA50检测可作为肝癌辅助诊断的一项重要指标。与AFP联合检测，能提高诊断的敏感性。
Objective To investigate the value of serum carbohydrate antigen 50 (CA50) in the diagnosis of primary liver cancer. Methods The level of serum CA50 in 38 patients with primary liver cancer was detected by IRMA method, and compared with 43 cases of benign liver disease and 20 normal controls. Results The serum CA50 of HCC patients was significantly higher than that of benign liver disease patients and normal controls (P <0.05). The sensitivity of CA50 in diagnosing HCC was 57.8%. The sensitivity of combined detection of AFP and HCC in diagnosing HCC was 65.7% and 89.4%, respectively. Conclusion In primary hepatocellular carcinoma, serum CA50 detection can be used as an important indicator for the diagnosis of liver cancer. Combined with AFP test, can improve the diagnostic sensitivity.