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目的:观察抗骨松胶囊治疗绝经后骨质疏松症的临床疗效。方法:选取80例绝经后骨质疏松症患者,随机分为2组。中药组48例给予抗骨松胶囊,钙剂组32例给予钙尔奇D,治疗6月。治疗前后采用双能X线骨密度测量仪测量腰椎L2～4的骨密度,检测血清骨钙素、抗酒石酸酸性磷酸酶5b水平,观察骨痛改善程度。结果:中药组及钙剂组经治疗6月后,L2～4骨密度均有不同程度升高,中药组治疗前后比较,差异有非常显著性意义(P<0.01),钙剂组治疗前后比较,差异无显著性意义(P>0.05)。治疗后2组骨密度比较,差异有非常显著性意义(P<0.01)。治疗前2组骨钙素、抗酒石酸酸性磷酸酶5b比较,差异均无显著性意义(P>0.05)。中药组治疗前后比较,骨钙素差异有非常显著性意义(P<0.01),抗酒石酸酸性磷酸酶5b差异有显著性意义(P<0.05)。钙剂组治疗前后比较,差异均无显著性意义(P>0.05)。治疗后2组骨钙素、抗酒石酸酸性磷酸酶5b比较,差异均有显著性意义(P<0.05)。骨痛疗效总有效率中药组为89.58%,钙剂组为59.38%,2组比较,差异有显著性意义(P<0.05)。疼痛缓解平均时间中药组10～14天,钙剂组30天左右。结论:抗骨松胶囊治疗绝经后骨质疏松症疗效显著可靠。
Objective: To observe the clinical efficacy of Kangugusong Capsule in the treatment of postmenopausal osteoporosis. Methods: Eighty menopausal osteoporosis patients were randomly divided into two groups. 48 cases in the traditional Chinese medicine group were given anti-Gusong capsule, and 32 cases in the calcium group were treated with Guric D for 6 months. Before and after treatment, BMD of L2 ~ 4 in lumbar spine was measured by dual-energy X-ray absorptiometry. Serum levels of osteocalcin and tartrate-resistant acid phosphatase 5b were measured to observe the degree of improvement of bone pain. Results: After treatment for 6 months, the BMD of L2 ~ 4 increased in different degrees in traditional Chinese medicine group and calcium group, and there was significant difference between before and after treatment in traditional Chinese medicine group (P <0.01), before and after treatment , No significant difference (P> 0.05). After treatment, there was a significant difference between the two groups in bone mineral density (P <0.01). There was no significant difference between the two groups before treatment of osteocalcin and tartrate-resistant acid phosphatase 5b (P> 0.05). There were significant differences in osteocalcin between the TCM group before and after treatment (P <0.01), and the difference between the tartrate-resistant and acid phosphatase 5b groups (P <0.05). Calcium group before and after treatment, the difference was not significant (P> 0.05). After treatment, the difference between the two groups of osteocalcin and tartrate-resistant acid phosphatase 5b was significant (P <0.05). The total effective rate of bone pain was 89.58% in traditional Chinese medicine group and 59.38% in calcium group. There was significant difference between the two groups (P <0.05). The pain relief average time of Chinese medicine group 10 to 14 days, calcium group about 30 days. Conclusion: GuGusong Capsule is effective and reliable in the treatment of postmenopausal osteoporosis.