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本文对14例肝癌患者外科手术前后血清糖抗原CA_(50) 、癌胚抗原(CEA)、β_2-微球蛋白(β_2-M)、铁蛋白(Ft),用放射免疫方法进行了测定。结果表明,CA_(50)术前阳性率为71％,术后阳性率为81％。CEA、β_2-M、Ft的变化与CA_(50)基本相似。同时四种肿瘤标志物联合测定的阳性率明显高于单项标志物的阳性率,认为如果动态观测其标志物的变化,对肿瘤的治疗、预后有重要的临床意义。
In this paper, the serum carbohydrate antigens CA_(50), carcinoembryonic antigen (CEA), β 2 -microglobulin (β 2 -M), and ferritin (Ft) were determined by radioimmunoassay before and after surgery in 14 patients with hepatocellular carcinoma. The results showed that the preoperative positive rate of CA_(50) was 71%, and the positive rate after surgery was 81%. The changes of CEA, β_2-M and Ft are basically similar to CA_(50). At the same time, the positive rate of combined determination of four tumor markers was significantly higher than the positive rate of single markers. It is believed that if the dynamic observation of the changes of the markers, it has important clinical significance for the treatment and prognosis of tumors.