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目的:探讨肿瘤坏死因子-α(TNF-α)对血管内皮细胞ICAM-1表达的诱导作用。方法:通过血管内皮细胞培养,采用免疫组织化学方法分别观察不同浓度(0~250U·ml-1)TNF-α24小时内及某一浓度(100U·ml-1)TNF-α在不同时程(0~72h)对内皮细胞ICAM-1表达的影响。结果:与对照组比较,TNF-α呈浓度与时间依赖性诱导内皮细胞ICAM-1的表达。结论:TNF-α是诱导血管内皮细胞表达ICAM-1的直接原因之一。
Objective: To investigate the induction of tumor necrosis factor-α (TNF-α) on the expression of ICAM-1 in vascular endothelial cells. Methods: The expression of TNF-α in different concentrations (0 ~ 250U · ml-1) of TNF-α within 24 hours and in a certain concentration (100U · ml-1) were detected by immunohistochemical method in vascular endothelial cells 0 ~ 72h) on the expression of ICAM-1 in endothelial cells. Results: Compared with the control group, TNF-αinduced the expression of ICAM-1 in endothelial cells in a time-and concentration-dependent manner. Conclusion: TNF-α is one of the direct causes of ICAM-1 expression in vascular endothelial cells.