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目的观察应用左炔诺孕酮内缓释系统治疗功能失调性子宫出血的临床疗效。方法选取2010年2月至2013年4月商丘市妇幼保健院妇产科收治的60例围绝经期功能失调性子宫出血患者,采取左炔诺孕酮内缓释系统进行治疗,跟踪观察治疗后3、6、12个月患者的月经量、子宫内膜厚度、血红蛋白浓度等。结果治疗后3、6、12个月的月经量与治疗前比较下降60%、73%、89%,患者经治疗后子宫内膜厚度降低、月经量减少、血红蛋白浓度升高,并且在治疗第6、第12个月后患者的子宫内膜厚度、月经量、血红蛋白浓度改善更为明显,与治疗前比较具有统计学意义(P<0.05)。结论应用左炔诺孕酮内缓释系统治疗功能失调性子宫出血疗效明显,可以作为治疗女性围绝经期功能失调性子宫出血的有效方法。
Objective To observe the clinical efficacy of levonorgestrel sustained release system in the treatment of dysfunctional uterine bleeding. Methods Sixty patients with dysfunctional uterine bleeding during peri-menopausal period admitted to Obstetrics and Gynecology Hospital of Shangqiu MCH from February 2010 to April 2013 were selected and treated with levonorgestrel sustained-release system. After follow-up observation, 3,6,12 months of patients with menstrual flow, endometrial thickness, hemoglobin concentration and so on. Results The amount of menstruation at 3, 6 and 12 months after treatment decreased by 60%, 73% and 89% respectively. The thickness of endometrium decreased, menstruation decreased and hemoglobin concentration increased after treatment. The endometrial thickness, menstrual volume and hemoglobin concentration of the patients after 12 months were more obviously improved than those before treatment (P <0.05). Conclusion The application of levonorgestrel sustained-release system in treatment of dysfunctional uterine bleeding has obvious curative effect and can be used as an effective method to treat dysfunctional uterine bleeding in perimenopausal women.