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3注射给药脂质体的应用注射用脂质体用于基因治疗较多。基因治疗是近20年来随着现代医学和分子生物学的发展而诞生的。目前已被广泛应用于肿瘤和遗传性疾病治疗的临床试验。脂质体作为外源基因的载体,具有显著的优点。比如:磷脂成分无毒、无免疫原性、安全可靠;可运载不同大小的基因片段,可运载质粒DNA而成为载体的载体,还可运载染色体或细胞核,其载药量大大超过其它载体;可抵御核酸酶的作用,延缓基因降解;脂质与细胞融合后,重组基因导入细胞,脂质体即被降解,磷脂可被细胞生物膜利用;制备工艺简便。因此,美国重组DNA咨询委员会已批准非病毒载体—
3 injection administration liposomes for injection liposomes for gene therapy more. Gene therapy is the birth of modern medicine and molecular biology in the past 20 years. Has been widely used in cancer and genetic disease treatment of clinical trials. Liposomes as a foreign gene carrier, with significant advantages. For example: phospholipid ingredients non-toxic, non-immunogenicity, safe and reliable; can carry different size of the gene fragments can carry plasmid DNA and become the carrier of the carrier, but also carry chromosomes or nuclei, the drug load much more than other carriers; Resist the action of nuclease and delay the gene degradation; after the lipid is fused with the cell, the recombinant gene is introduced into the cell, the liposome is degraded and the phospholipid can be utilized by the cell biofilm; the preparation process is simple and convenient. As a result, the US Recombination DNA Advisory Committee has approved non-viral vectors -