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药物药效的发挥与其在机体内始终处在吸收、分布、代谢、排泄这种动态变化的过程密不可分,而吸收作为口服药物进入机体的首要环节格外受到重视。中药作为多成分与多靶点的药物,单一成分的性质与其在多成分环境中所表现出来的性质会有差别。该文以黄连提取物中的生物碱为主要研究对象,建立黄连中生物碱成分含量测定的分析方法。并通过离体翻转肠囊实验及肠道灌流并行采血实验初步锁定黄连水提液中可透过肠壁吸收并吸收入血的成分,为后续对黄连多成分的吸收代谢研究提供数据参考与支持。
Drug efficacy and its role in the body is always in the absorption, distribution, metabolism, excretion of this dynamic process of change are inseparable, and absorption as an oral drug into the body of the most important aspects of special attention. Traditional Chinese medicine as a multi-component and multi-target drugs, the nature of a single component and its performance in a multi-component environment will be different. This article takes the alkaloids in the extract of Coptidis Rhizoma as the main research object, and establishes the analytical method for the determination of alkaloids in Coptis chinensis. In vitro experiments of intestinal follicles and bowel perfusion were carried out to lock the components of the water extract of Rhizoma Coptidis which could be absorbed through the intestinal wall and absorbed into the blood, which provided data reference and support for subsequent studies on the absorption and metabolism of Coptis chinensis .