论文部分内容阅读
甘氨脱氧胆酸(Glycodeoxycholic Acid,GDCA)引起肝细胞损伤多见报道，但其机理研究甚少。为了解GDCA对肝细胞损伤的机制，本文拟观察GDCA诱导大鼠肝细胞内游离Ca2+浓度([Ca2+]i)的变化，探讨GDCA是否通过Ca2+而导致肝细胞损伤。1 材料与方法1.1 材料：Wister雄性大鼠，体重200
Glycodeoxycholic acid (GDCA) caused hepatocyte damage more commonly reported, but the mechanism of little research. In order to understand the mechanism of GDCA on liver cell damage, this paper intends to observe the changes of intracellular free Ca2 + concentration ([Ca2 +] i) induced by GDCA in rats and whether hepatocellular injury caused by GDCA via Ca2 +. 1 Materials and Methods 1.1 Materials: Wister male rats weighing 200