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采用丙烯酰胺+2-乙烯基吡啶的复合碱性功能单体体系制备了氨基酸衍生物分子烙印高效液相色谱手性固定相.在优化了功能单体与烙印分子的比例条件下对于烙印分子及其结构相似的对映体具有良好的手性分离能力.考察了烙印分子的化学基因对手性分离的影响,发现氢键作用力和较强的离子作用力在手性分离过程中均有贡献.
Amino acid derivative molecular imprinted high performance liquid chromatography (HPLC) chiral stationary phase was prepared by using complex basic functional monomer system of acrylamide + 2-vinylpyridine.After optimizing the ratio of functional monomer to imprinting molecule, The enantiomers with similar structures have good chiral separation ability, and the influence of the chemical genes of the imprinted molecules on the chiral separation has been investigated. It is found that both the hydrogen bonding force and the strong ionic force contribute to the chiral separation.