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目的探讨血清胱抑素C(CysC)作为肾小球滤过率指标在评估肾功能损害的临床应用价值。方法采用乳胶颗粒增强免疫比浊法测定110例健康体检者和96例高危肾病患者和94例肾病患者血清中CysC的浓度,并与血尿素(Urea),血肌酐(Scr)进行比较。结果高危肾病组CysC水平高于对照组(P<0.05)。肾病组CysC、Urea及Scr水平均高于对照组(P<0.01)。对照组、高危肾病组Urea、Scr水平比较差异无统计学意义(P>0.05)。结论血清CysC指标在临床评估肾功能损害方面,是一个比Urea、Scr更为准确、可靠、灵敏的指标。
Objective To investigate the clinical value of serum cystatin C (CysC) as a marker of glomerular filtration rate in assessing renal dysfunction. Methods Serum levels of CysC in 110 healthy subjects, 96 high risk nephropathy patients and 94 nephropathy patients were determined by latex particle enhanced immunoturbidimetry and compared with those of Urea and Scr. Results The level of CysC in high risk group was higher than that in control group (P <0.05). Nephropathy group CysC, Urea and Scr levels were higher than the control group (P <0.01). There was no significant difference in Urea and Scr between the control group and the high risk nephropathy group (P> 0.05). Conclusion Serum CysC index is a more accurate, reliable and sensitive index than Urea and Scr in the clinical evaluation of renal dysfunction.