[目的]探讨胆固醇与Zn2+之间的相互作用。[方法]采用TPPS4：α，β，γ，δ─四（对磺基苯基）卟啉（分子式Na4C44O24H34N4S4）分光光度法[1]测定在不同的条件下，在水溶液中胆固醇对Zn2+的吸附。[结果]胆固醇与Zn2+的相互作用主要是物理吸附，最佳吸附条件为：吸附时间为60分钟，吸附温度37℃，pH值7～8，胆固醇的量约为0．1g。[结论]得出胆固醇与Zn2+相互作用主要是物理吸附，其他微量元素也影响胆固醇对Zn2+的吸附。 [Objective] To explore the interaction between cholesterol and Zn2 +. [Method] The TPPS4: α, β, γ, δ-tetrakis (p-sulfophenyl) porphyrin (Na4C44O24H34N4S4) spectrophotometry was used to determine the adsorption of Zn2 + by cholesterol in aqueous solution under different conditions. [Result] The interaction between cholesterol and Zn2 + was mainly physical adsorption. The optimum adsorption conditions were as follows: the adsorption time was 60 minutes, the adsorption temperature was 37 ℃, the pH value was 7-8 and the cholesterol content was about 0.1g. [Conclusion] The results show that the interaction between cholesterol and Zn2 + is mainly physical adsorption, and other trace elements also affect the adsorption of cholesterol to Zn2 +.