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目的 分析尿毒症血液透析(HD)患者血脂变化的原因.方法 测定54例尿毒症血液透析患者血清甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、载脂蛋白(apo)AI及B的含量,与30例正常人进行对照研究.结果 患者组透析前、后的血TG、LDL、HDL、apoAI及apoB含量与对照组相比均有显著差异(p<0.01),而尿毒症患者组透析前、后的血清脂质含量相比无明显差异p>0.05.结论 尿毒症时脂质代谢发生紊乱,是促进动脉粥样硬化、缺血性心、脑血管损害的重要原因,HD不能纠正其代谢紊乱,也不能降低心、脑血管疾病的发病率.
Objective To analyze the causes of blood lipid changes in uremic hemodialysis (HD) patients.Methods Serum triglyceride (TG), total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein (HDL), apolipoprotein (AI), and B were compared with those of 30 normal subjects.Results The levels of TG, LDL, HDL, apoAI and apoB in the patients before and after dialysis were significantly higher than those in the control group There was a significant difference (p <0.01), while there was no significant difference in serum lipid levels between before and after dialysis in uremia patients.ConclusionDyslipidemia is a disorder of uremia, promoting atherosclerosis, lacking Hemorrhagic heart, cerebrovascular damage, an important reason, HD can not correct its metabolic disorders, can not reduce the incidence of cardiovascular and cerebrovascular diseases.