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[目的]通过对2008～2011年山东省肾综合征出血热疫情分析,了解现阶段山东省HFRS流行规律,为防治制定策略。[方法]采用Excel和Epidata 8对山东省各地2008～2011年HFRS发病和死亡时间、病例构成变化及对疫情的影响进行分析;采用间接免疫荧光检测鼠肺汉坦病毒抗原。[结果]自2008年起山东省HFRS进入第五个流行周期,疫情东移倾向进一步明确,病例分布呈现既分散又相对集中的特点,发病以鲁东南丘陵地区和胶莱平原部分地区为主,鲁西北平原和鲁中南山区呈下降趋势;2008～2011年山东省HFRS发病以农民为主,占发病例数的83.20%,男女之比2.79∶1;以25～65岁年龄组发病较多;汉坦病毒(HV)宿主室内外均以褐家鼠和小家鼠为主,春季和秋季HV抗原阳性率分别为2.06%和1.89%。[结论]应继续采取防鼠灭鼠、预防接种和健康教育为主的防治对策,抓好重点地区HFRS防治。
[Objective] Based on the analysis of the epidemic situation of hemorrhagic fever with renal syndrome in Shandong Province from 2008 to 2011, the prevalence of HFRS in Shandong Province at this stage was analyzed to make strategies for prevention and treatment. [Methods] The incidence of HFRS, the time of death, the changes of case composition and the impact on epidemic situation of HFRS in Shandong Province from 2008 to 2011 were analyzed by Excel and Epidata 8. The indirect immunofluorescence was used to detect Hantavirus antigen in mouse lung. [Results] Since HFRS entered the fifth epidemic cycle in Shandong Province in 2008, the tendency of the eastward spread of the epidemic was further clarified. The distribution of cases showed both scattered and relatively concentrated characteristics. The incidence was mainly in the hilly areas in eastern Shandong and parts of the Jiaolai Plain, The incidence of HFRS in Shandong Province was mainly from peasants in 2008-2011, accounting for 83.20% of cases and the ratio of male to female was 2.79:1. The incidence of HFRS was higher in 25-65 years old group; Hantavirus (HV) hosts were dominated by Rattus norvegicus and Mus musculus both in vitro and in vivo. The positive rates of HV antigen in spring and autumn were 2.06% and 1.89%, respectively. [Conclusion] The prevention and control measures should be taken to prevent rodent control, vaccination and health education, and prevention and treatment of HFRS in key areas should be taken.