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目的比较丹参提取物Ｆ（ＤＳＥＦ）与西咪替丁（ＣＩ）抗胃窦部粘膜再灌注损伤作用。方法以Ｉｔｏｈ法复制大鼠失血性休克再灌注损伤模型。１９只Ｗｉｓｔａｒ大鼠随机分为生理盐水组（ＮＳ，ｎ＝７）、丹参提取物Ｆ组（ＤＳＥＦ，ｎ＝６）及西咪替丁组（ＣＩ，ｎ＝６），分别于尾静脉静注生理盐水、ＤＳＥＦ１ｇ／１００ｇ ｗｔ及 ＣＩ６．５ｍｇ／１００ｇ ｗｔ。测定胃窦部粘膜损伤指数、损伤深度、细胞内钙含量及粘膜前列腺素含量。结果（ １）ＤＳＥＦ组及 ＣＩ组的胃窦部粘膜损伤指数及 ２、 ３级损伤均明显低于 ＮＳ组（ Ｐ＜０．０１或０．０５）；ＤＳＥＦ组的３级损伤又明显低于ＣＩ组（Ｐ＜０．０５）。（２）ＤＳＥＦ组６－ｋ／ＴＸＢ２比值明显高于ＮＳ及ＣＩ组（Ｐ＜０．０１，０．０５）；而ＴＸＢ２的含量明显低于ＮＳ组（Ｐ＜０．０５）。ＣＩ组各前列腺素含量与 ＮＳ组比无显著性差异（ Ｐ＞ ０．０５）。（３） ＤＳＥＦ组及 ＣＩ组的细胞内钙含量明显低于 ＮＳ组（ Ｐ＜０．０１）；而ＤＳＥＦ组与ＣＩ组间无显著性差异（Ｐ＞０．０５）。结论ＤＳＥＦ与ＣＩ均具有抗胃窦部粘膜再灌注损伤的作用，但ＤＳＥＦ更能阻止深度损伤的发生，且二者作用机制不尽相同。
Objective To compare the anti-mucosal reperfusion injury effects of Salvia miltiorrhiza extract F (DSEF) and cimetidine (CI) in gastric antrum. Methods Rat model of hemorrhagic shock and reperfusion was reproduced by Itoh method. Nineteen Wistar rats were randomly divided into normal saline group (NS, n = 7), Danshen extract F group (DSEF, n = 6) and cimetidine group (CI, n = 6) Saline, DSEF1g / 100g wt and CI6.5mg / 100g wt. Gastric mucosal injury index, depth of injury, intracellular calcium content and mucosal prostaglandin content were measured. Results (1) The gastric mucosal lesion index and grade 2 and 3 lesions of DSEF group and CI group were significantly lower than those of NS group (P <0.01 or 0.05). The grade 3 lesion in DSEF group and CI group was significantly lower than that of NS group CI group (P <0.05). (2) The 6-k / TXB2 ratio in DSEF group was significantly higher than that in NS and CI groups (P <0.01, 0.05), while the content of TXB2 was significantly lower than that in NS group (P <0.05). The content of prostaglandin in CI group was not significantly different from NS group (P> 0.05). (3) The intracellular calcium contents in DSEF group and CI group were significantly lower than those in NS group (P <0.01). There was no significant difference between DSEF group and CI group (P> 0.05). Conclusions Both DSEF and CI have anti-mucosal reperfusion injury in gastric antrum, but DSEF can prevent the deep injury and the mechanism of action is different.