论文部分内容阅读
1.从硝基苯胺及其取代物经三步反应合成六种氨基-甲基(或烷氧基)-吲(口朶)-2-羧酸乙酯(Ⅱ)。 2.两种氨基-甲基-吲(口朶)-2-羧酸乙酯(Ⅱb和Ⅱc)经羟乙基化后得5-[双-(β-羟乙基)-氨基]-3-甲基-吲(口朶)-2-羧酸乙酯(Ⅵa)和4-[双-(β-羟乙基)-氨基]-7-甲基-吲(口朶)-2-羧酸乙酯(Ⅵb)。 3.由硝基-吲(口朶)-2-羧酸酯(Ⅻa及Ⅻb)经脱羧及催化氢化制得5-氨基-吲(口朶)(Ⅸa)和7-氨基-吲(口朶)(Ⅸb)。
1. Synthesis of six amino-methyl (or alkoxy) -indolesters (2-carboxylates) from nitroaniline and its substitutes in three steps. 2. Hydroxyethylation of two amino-methyl-indoles (estradiol) -2-carboxylates (IIb and IIc) gave 5- [bis- (β-hydroxyethyl) -amino] (Oral) -2-carboxylate (VIa) and 4- [bis- (β-hydroxyethyl) -amino] -7-methyl- Ethyl acetate (VIb). 3. Preparation of 5-Amino-indoles (Ⅸa) and 7-Amino-indoles from the nitro-indole-2-carboxylates (Ⅻa and Ⅻb) by decarboxylation and catalytic hydrogenation ) (IXb).