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目的:分析窄波紫外线(NB-UVB)单用及联合干扰素等治疗Ⅰ、Ⅱ期蕈样肉芽肿的临床疗效。方法:回顾性分析北京大学第一医院皮肤科2009年1月—2013年12月诊治并随访的64例经临床和组织病理证实为Ⅰ、Ⅱ期蕈样肉芽肿并接受了NB-UVB,NB-UVB联合干扰素,NB-UVB联合干扰素、甲氨蝶呤(MTX)、小剂量糖皮质激素和(或)阿维A等方案治疗的患者临床资料。结果:64例蕈样肉芽肿(ⅠA期15例,ⅠB期33例,ⅡA期10例,ⅡB期6例),经NB-UVB,NB-UVB联合干扰素,NB-UVB联合干扰素、MTX、小剂量糖皮质激素和(或)阿维A治疗等方案治疗,有效率分别为:91.18%、86.67%和53.33%。其中ⅠA-ⅡA期中完全缓解(CR)19例(32.76%)、部分缓解(PR)30例(51.72),有效率84.48%。ⅡB期中CR1例(16.67%),PR1例(16.67%),有效率33.33%。结论:NB-UVB及NB-UVB联合干扰素治疗早期MF(ⅠA期、ⅠB-ⅡA期)效果优于ⅡB期,NB-UVB联合干扰素、MTX、小剂量糖皮质激素和(或)阿维A方案治疗ⅡB期MF有一定疗效。
Objective: To analyze the clinical efficacy of narrow-band ultraviolet (NB-UVB) single and combination interferon in the treatment of stage Ⅰ and Ⅱ mycosis fungoides. Methods: Sixty-four patients with mycosis fungoides I and II confirmed by clinical and histopathological examination from January 2009 to December 2013 were retrospectively analyzed. NB-UVB, NB -UVB combined with interferon, NB-UVB combined with interferon, methotrexate (MTX), low-dose glucocorticoid and (or) Avi A treatment of patients with clinical data. Results: Sixty-four cases of mycosis fungoides were identified as NB-UVB combined with interferon, NBXB combined with interferon, NBXB combined with interferon, MTX , Low-dose glucocorticoid and / or Avi A treatment programs, the effective rates were: 91.18%, 86.67% and 53.33%. Nineteen patients (32.76%) had complete remission (CR) and 30 (51.72) had partial remission (PR) in ⅠA-ⅡA. The effective rate was 84.48%. In stage ⅡB, CR1 cases (16.67%) and PR1 cases (16.67%), the effective rate was 33.33%. Conclusion: The combination of NB-UVB and NB-UVB combined with interferon is better than that of phase IIB in early MF (stage IA, IB-IIA), NB-UVB combined with interferon, MTX, low dose glucocorticoid and / A program of treatment Ⅱ B MF have a certain effect.