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本文报道1株抗人活化血小板的单克隆抗体——SZ-49。SZ-49仪和凝血酶刺激活化的血小板结合,而不与静止的血小板反应,为IgG1亚型。它和活化血小板结合是Ca~(2+)依赖性的,对血小板功能有明显的影响,SZ-49亲和层析获得的纯化抗原为小分子量蛋白。这种新的单克隆抗体为研究血小板活化过程中的系列改变及疾病状态下体内,外血小板活化程度的评估提供了新的方法。
This article reports a monoclonal anti-human activated platelet antibody SZ-49. SZ-49 instrument and thrombin stimulate the activation of activated platelets, but not with resting platelets, IgG1 isotype. Its binding to activated platelets is Ca ~ (2+) dependent and has a significant effect on platelet function. The purified antigen obtained from SZ-49 affinity chromatography is a small molecular weight protein. This new monoclonal antibody provides a new way to study serial changes in platelet activation and assessment of platelet activation in vitro and in vivo under disease conditions.