论文部分内容阅读
目的分析丙基硫氧嘧啶(PTU)对~(131)I 治疗 Graves 病疗效的影响。方法 234例Graves 病患者中,36例首选~(131)Ⅰ治疗者为对照(N)组,经过 PTU 治疗的198例患者随机分为 A、B 组。N 组和 A 组均按甲状腺质量给予~(131)I 2.96 MBq/g,B 组每克甲状腺组织~(131)I 剂量较前2组增加30%。治疗6个月后,比较3组患者的疗效,计算治愈率和近期甲状腺功能减退症(简称甲减)发生率。结果 234例 Graves 病患者~(131)I 治疗总有效率为99.1%。N 组治愈率为86.1%,A 组为68.7%,后者明显低于前者(P<0.05)。B 组治愈率为85.9%,与 N 组差别不大,但与 A 组比较差异有统计学意义(P<0.01)。结论 PTU 可直接影响~(131)I 治疗 Graves 病的近期疗效,但增加每克甲状腺组织的~(131)I 剂量可减少其影响。
Objective To analyze the effect of propylthiouracil (PTU) on the therapeutic effect of ~ (131) I on Graves disease. Methods Of 234 patients with Graves’ disease, 36 patients who preferred ~ (131) Ⅰ treatment were control group (N). 198 patients who underwent PTU were randomly divided into A and B groups. The dose of ~ (131) I 2.96 MBq / g in group N and group A was increased by thyroid mass, and the dose of ~ (131) I in group B was increased by 30%. After 6 months of treatment, the efficacy of the three groups of patients was compared, and the cure rate and the incidence of hypothyroidism (hypothyroidism) were calculated. Results The total effective rate of ~ (131) I in 234 patients with Graves disease was 99.1%. The cure rate was 86.1% in group N and 68.7% in group A, which was significantly lower than the former (P <0.05). The cure rate in group B was 85.9%, which was not significantly different from that in group N, but the difference was statistically significant compared with group A (P <0.01). Conclusions PTU can directly influence the short-term curative effect of ~ (131) I treatment of Graves’ disease, but increasing the dose of ~ (131) I per gram of thyroid tissue can reduce its influence.