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目的：探讨线粒体转录因子A（ TFAM）基因多态性与精神分裂症的关系。方法：采用PCR-RFLP及DNA序列分析技术分别对237例精神分裂症患者及246例健康对照TFAM基因rs10826178、rs4390300两多态位点进行检测及分析。结果：rs10826178与rs4390300位点等位基因与基因型频率分布在两组之间比较，差异无统计学意义（P均＞0．05）。结论：TFAM基因rs4390300、rs10826178的基因型差异可能与精神分裂症的发病无关。“,”Aim:To research the relationship between mitochondrial transcription factor A ( TFAM) gene′s two poly-morphic loci and schizophrenia .Methods: The PCR-RFLP analysis and DNA sequencing technology were used to detect polymorphism of rs10826178 and rs4390300 in 237 cases of schizophrenia(patient group) and 246 healthy subjects(control group) .Results:The genotype frequencies and allele frequencies of TFAM gene rs 10826178 and rs4390300 in the two groups had no differences(P>0.05).Conclusion:TFAM gene rs10826178 and rs4390300 polymorphisms may not be as-sociated with schizophrenia .