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目的:探讨磷酸肌酸钠对急性冠脉综合征患者的临床预防和治疗作用。方法:选取120例急性冠脉综合征患者,59例行常规治疗,包括给氧、抗血小板、抗凝、扩张冠脉、营养心肌、止痛等。61例患者在常规治疗的基础上加用磷酸肌酸钠1g,静脉滴注,1次/d,共7d。结果:①使用磷酸肌酸钠的急性冠脉综合征病人较未使用的心律失常的发生率明显降低;②使用磷酸肌酸钠的急性心肌梗死病人较未使用的血清磷酸肌酸激酶(CK)及M B同功酶明显降低;③未用磷酸肌酸钠的急性冠脉综合征病人较使用的心功能明显减低;④使用磷酸肌酸钠的急性冠脉综合征病人较未使用的节段性室壁运动异常的发生率明显减少。结论:磷酸肌酸钠能显著改善急性冠脉综合征患者的心肌代谢、减轻心肌损伤、保护心功能、减少心律失常等并发症的发生。
Objective: To investigate the clinical efficacy of sodium creatine phosphate in the prevention and treatment of acute coronary syndrome. Methods: A total of 120 patients with acute coronary syndrome were enrolled. Fifty-nine patients were given conventional therapy including oxygenation, antiplatelet, anticoagulation, coronary artery dilation, nourishing myocardium and analgesia. 61 patients on the basis of conventional therapy plus 1g sodium creatine, intravenous infusion, 1 time / d, a total of 7d. Results: ① The incidence of acute coronary syndrome patients using sodium creatine phosphate was significantly lower than that of unused cardiac arrhythmias; ② Compared with unused serum creatine phosphokinase (CK), the patients with acute myocardial infarction using sodium creatine phosphate And MB isoenzyme was significantly reduced; ③ did not use sodium creatine phosphate in patients with acute coronary syndrome compared with the use of cardiac function was significantly reduced; ④ the use of sodium creatine phosphate in patients with acute coronary syndrome than unused segmental The incidence of abnormal wall motion was significantly reduced. Conclusion: Sodium creatine phosphate can significantly improve myocardial metabolism in patients with acute coronary syndrome, reduce myocardial damage, protect cardiac function and reduce complications such as arrhythmia.