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目的观察血必净注射液对应用血液灌流治疗急性重度有机磷中毒(AOPP)的疗效。方法将107例AOPP患者并应用血液灌流治疗的患者随机分为两组:对照组54例给予常规洗胃、导泻、解毒药物及血液灌流等规治疗。治疗组53例在对照组基础上,加用血必净注射液治疗,对比观察两组的死亡率、入住急诊监护室(EICU)的时间、血清胆碱酯酶活性、血乳酸值、TNF-α、血液灌流持续时间及全身炎症反应综合征(SIRS)持续时间。结果两组患者的死亡率、血清胆碱酯酶活性无统计学差异(P>0.05),治疗组在EICU停留时间更短(P<0.05),治疗组的血乳酸值、TNF-α有明显下降,血液灌流持续时间无统计学差异(t=1.731,P=0.1175),治疗组的SIRS持续时间明显缩短,组间比较差异有统计学意义(t=5.810,P=0.0003)。结论在应用血液灌流治疗AOPP,血必净注射液能缩短患者病程并有效抑制患者伤后过度的炎症反应,更早减轻临床症状,利于病情恢复。
Objective To observe the effect of Xuebijing injection on acute severe organophosphorus poisoning (AOPP) with hemoperfusion. Methods A total of 107 patients with AOPP who were treated with hemoperfusion were randomly divided into two groups: control group (n = 54) received conventional gastric lavage, catharsis, detoxification drugs and hemoperfusion. 53 cases in the treatment group were treated with Xuebijing injection on the basis of the control group. The mortality of the two groups, the time of EICU, serum cholinesterase, blood lactate, TNF- α, duration of hemoperfusion, and duration of systemic inflammatory response syndrome (SIRS). Results There was no significant difference in mortality and serum cholinesterase between the two groups (P> 0.05). The retention time of EICU in the treatment group was shorter (P <0.05), and the blood lactate level and TNF-α in the treatment group were significantly higher (T = 1.731, P = 0.1175). The duration of SIRS in the treatment group was significantly shorter and the difference between the two groups was statistically significant (t = 5.810, P = 0.0003). Conclusion In the application of hemoperfusion for AOPP, Xuebijing Injection can shorten the course of patients and effectively inhibit excessive inflammation in patients with post-traumatic injury, relieve clinical symptoms earlier and facilitate the recovery of the disease.