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目的:评价液氮冷冻联合兰科肤宁治疗孕妇尖锐湿疣的临床疗效与安全性。方法:回顾性分析我院收治的46例患有尖锐湿疣的孕妇,平均年龄为27岁,妊娠平均18周。每例患者的病灶数为5~18个。应用液氮枪喷涂于皮损,液氮枪距皮损2-3 cm,喷雾时间60秒,重复操作直至喷嘴霜化。将蓝科肤宁喷涂于单层纱布,敷于皮损部位20分钟,每天2-3次,共1周。分别于治疗后1月、3月观察皮损愈合情况,评价治疗效果。结果:治疗5天后,皮损均治愈,所有患者除有轻度至中度疼痛外,无其他不适。治疗后1个月,满意度94%;治疗后3个月,满意度为87%。无色素脱失或瘢痕形成,无任何严重不良事件。每位孕妇均分娩出一个健康的婴儿,无分娩相关并发症。治疗后1个月,只有1例病人复发,复发率为2.2%。治疗后3月,5例复发,复发率为10.9%。结论:液氮冷冻联合蓝科肤宁治疗孕妇尖锐湿疣的近期疗效较好,安全性较高。
Objective: To evaluate the clinical efficacy and safety of liquid nitrogen freezing combined with Lankefuxin for the treatment of condyloma acuminatum in pregnant women. Methods: Retrospective analysis of 46 pregnant women with condyloma acuminatum treated in our hospital, with an average age of 27 years and an average pregnancy of 18 weeks. Each patient has 5 to 18 lesions. Application of liquid nitrogen gun sprayed on the skin lesions, liquid nitrogen gun lesions 2-3 cm, spray time 60 seconds, repeat until the nozzle cream. The Blue Branch skin spraying rather than a single gauze, deposited in the lesion site for 20 minutes 2-3 times a day for a total of 1 week. Respectively in January and March after treatment to observe the healing of skin lesions, evaluate the therapeutic effect. Results: After 5 days of treatment, skin lesions were cured. All patients had no discomfort except for mild to moderate pain. One month after treatment, the satisfaction rate was 94%. Three months after the treatment, the satisfaction rate was 87%. No depigmentation or scarring, no serious adverse events. Each pregnant woman gave birth to a healthy baby without complications related to childbirth. One month after treatment, only one patient relapsed with a recurrence rate of 2.2%. Three months after treatment, 5 patients relapsed with a recurrence rate of 10.9%. Conclusion: Liquid nitrogen freezing combined with Lankefuxin Ning pregnant women warts treatment of the recent better curative effect, higher safety.