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目的观察2型糖尿病(T2DM)患者D-二聚体,高敏C反应蛋白(hs-CRP)和胆红素与颈动脉粥样硬化(CAS)的关系。方法选取T2DM的患者147例,按照是否有CAS分为单纯糖尿病组(85例)和糖尿病合并CAS组(62例)。选取同期健康体检者30例为健康对照组。并观察各组hs-CRP、D-二聚体、糖化血红蛋白(HbA1C)和胆红素与CAS的关系。结果 hs-CRP、D-二聚体和HbA1C水平依次从健康对照组、单纯糖尿病组和DM合并CAS组递增,而胆红素中的TBIL和DBIL出现依次递减的变化,差异均有统计学意义(P<0.01),IBIL的各组水平差异无统计学意义(P>0.05)。糖尿病患者的hs-CRP、D-二聚体和HbA1C水平随着CAS分级的增加而增加(P<0.01),而胆红素中的TBIL和DBIL水平随着分级的增加出现递减,差异均有统计学意义(P<0.05或P<0.01),不同分级的IBIL水平差异无统计学意义(P>0.05)。结论 hs-CRP、D-二聚体、HbA1C和胆红素参与了T2DM的发病过程,与CAS形成有密切的关系。
Objective To investigate the relationship between D-dimer, high-sensitivity C-reactive protein (hs-CRP), bilirubin and carotid atherosclerosis (CAS) in type 2 diabetes mellitus (T2DM) Methods A total of 147 patients with T2DM were enrolled in this study. According to the presence of CAS, they were divided into simple diabetic group (85 cases) and diabetic combined CAS group (62 cases). Select the same period of 30 healthy physical examination for the healthy control group. The relationship between hs-CRP, D-dimer, HbA1C and bilirubin in CAS was observed. Results The levels of hs-CRP, D-dimer and HbA1C increased gradually from healthy control group, simple diabetic group and DM combined with CAS group, while TBIL and DBIL in bilirubin showed decreasing order, with statistical significance (P <0.01). There was no significant difference in each group of IBIL (P> 0.05). The levels of hs-CRP, D-dimer and HbA1C in diabetic patients increased with the increase of CAS grade (P <0.01), while the levels of TBIL and DBIL in bilirubin decreased with the increase of grade (P <0.05 or P <0.01). There was no significant difference in IBIL levels between different grades (P> 0.05). Conclusion hs-CRP, D-dimer, HbA1C and bilirubin are involved in the pathogenesis of T2DM and are closely related to the formation of CAS.