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目的了解我院尿路感染致病菌的分布及耐药性,为临床合理用药提供依据。方法收集2005年7月-2008年6月住院和门诊病人送检的尿培养标本,分离细菌并做药物敏感性试验。结果尿路感染分离的647株细菌中以大肠杆菌为主,占40.8%,其次为念珠菌属(28.2%)、肠球菌属(7.9%)、链球菌属(4.9%)、克雷伯菌属(3.6%)。革兰阳性球菌对万古霉素100%敏感,对呋喃妥因、氯霉素、利福霉素等较为敏感,对青霉素、红霉素、克林霉素耐药率高;革兰阴性杆菌对亚胺培南最敏感(耐药率为2.1%);对呋喃妥因、丁胺卡那、氨苄/舒巴坦、氨曲南、氯霉素等较为敏感,对青霉素类、一、二代头孢菌素耐药率高。结论我院念珠菌尿路感染所占比例较高,临床医生须合理选用抗菌药物,减少细菌耐药性的产生,预防二重感染,从而提高疗效。
Objective To understand the distribution and drug resistance of pathogenic bacteria in urinary tract infection in our hospital and provide basis for clinical rational drug use. Methods Urine culture samples collected from hospitalized patients and outpatients from July 2005 to June 2008 were collected and bacteria were separated for drug susceptibility testing. Results Among the 647 bacteria isolated from urinary tract infection, Escherichia coli accounted for 40.8%, followed by Candida (28.2%), Enterococcus (7.9%), Streptococcus (4.9%), Klebsiella Genus (3.6%). Gram-positive cocci is 100% sensitive to vancomycin, more sensitive to nitrofurantoin, chloramphenicol, rifamycins and so on, resistant to penicillin, erythromycin and clindamycin; Gram-negative bacilli to imine The most sensitive peinan (resistance rate of 2.1%); nitrofurantoin, amikacin, amoxicillin / sulbactam, aztreonam, chloramphenicol and other more sensitive to penicillins, first and second generation cephalosporin resistance High rate of medicine. Conclusion Candida albicans in our hospital a higher proportion of urinary tract infection, clinicians should be rational use of antimicrobial agents to reduce the generation of bacterial resistance, prevention of double infection, thereby enhancing the efficacy.