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目的探讨IgA肾病肾小动脉增厚的意义。方法对93例IgA肾病临床病理资料进行回顾性病例对照研究,运用单因素和多因素方法分析IgA肾病患者的临床指标及病理改变与肾小动脉增厚的关系。结果93例IgA肾病患者中有小动脉增厚者占59.1%,其中轻度占63.6%,中度占27.3%,重度占9.1%。肾小动脉重度增厚的患者临床病情和病理改变较肾小动脉轻度和中度增厚者严重(P<0.01);多因素分析显示高血压、血肌酐增高、球性硬化(≥50%)、间质炎性细胞浸润≥50%对IgA肾病小动脉增厚的发生影响有显著意义。结论IgA肾病肾小动脉增厚能够反映病变的程度,可以作为判断预后的一个重要病理指标。
Objective To investigate the significance of thickening of renal arterioles in IgA nephropathy. Methods A retrospective case-control study of 93 patients with IgA nephropathy was performed. The clinical and pathological changes of IgA nephropathy patients were analyzed by single factor and multivariate analysis. Results There were 59.1% cases of small artery thickening in 93 patients with IgA nephropathy, of which 63.6% were mild, 27.3% moderate and 9.1% were severe. Patients with severe arterial thickening had more serious clinical and pathological changes than mild and moderate thickening of renal arterioles (P <0.01). Multivariate analysis showed that hypertension, serum creatinine increased and sclerosis (≥50% ), Interstitial inflammatory cell infiltration ≥ 50% of the IgA nephropathy caused by the occurrence of thickening of the artery significant. Conclusion The thickening of renal arteries in IgA nephropathy can reflect the degree of pathological changes and can be used as an important pathological index to judge the prognosis.