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目的 观察大蒜对甲基硝基亚硝基胍 (MNNG)诱发大鼠前胃鳞癌及癌前病变的影响。方法 MNNG组、预防组、治疗组分别给予MNNG(每天 5ml,含MNNG 1.2 5mg)诱发大鼠前胃鳞癌及癌前病变 ,预防组另给 10 %大蒜匀浆 10ml/d ,10个月后停药。预防组与治疗组继续给大蒜匀浆 ,至 16个月。结果 MNNG组、预防组、治疗组分别诱发大鼠不典型增生 2 4只 (96 .0 % )、16只 (53.3% )和 9只 (4 5.0 % ) ,癌变 15只 (6 0 .0 % )、7只 (2 3.3% )和 4只 (2 0 .0 % )。经统计学处理 ,加用大蒜的预防组、治疗组与MNNG组均有显著性差异(P <0 .0 5)。结论 表明大蒜对MNNG诱发大鼠前胃鳞癌及癌前病变有抑制作用。
Objective To observe the effect of garlic on MNNG-induced precancerous squamous cell carcinoma and precancerous lesions in rats. Methods The MNNG group, prevention group and treatment group were given MNNG (5ml per day, containing MNNG 1.2 5mg) to induce pre-cancerous squamous cell carcinoma and precancerous lesions in rats. The prevention group was given another 10% garlic homogenate 10ml/d, 10 months later. Stop the drug. Prevention and treatment groups continued to homogenize garlic until 16 months. Results In the MNNG group, prevention group and treatment group, 24 (16.0%), 16 (53.3%) and 9 (45.0 %) atypical hyperplasias were induced, and 15 (60.0%) were cancerous. ), 7 (2 3.3%) and 4 (20.0%). After statistical analysis, there was a significant difference between the preventive group, the treatment group and the MNNG group (P < 0.05). CONCLUSIONS: Garlic has an inhibitory effect on MNNG-induced precancerous squamous cell carcinoma and precancerous lesions in rats.