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目的探讨Mimecan基因、核因子-κB(NF-κB)和白介素-24(IL-24)在子痫前期(preeclampsia,PE)中的表达及其相关性。方法根据子痫前期临床表现将98例子痫前期分为轻度子痫前期组(轻度PE组,53例)、重度子痫前期组(重度PE组,45例);选择正常健康孕妇48例作为对照组。采用酶联免疫法(ELISA)检测孕妇血清中Mimecan基因、NF-κB和IL-24的表达。结果子痫前期组患者Mimecan基因、NF-κB和IL-24的表达水平分别为(10.98±0.82)mg/L、(21.97±3.87)mg/L和(0.79±0.26)mg/L,对照组分别为(4.78±0.63)mg/L、(16.73±4.31)mg/L和(0.38±0.13)mg/L,两组比较,差异有统计学意义(P均<0.05);Mimecan基因、NF-κB和IL-24与子痫前期严重程度呈正相关(r分别为0.687、0.733和0.821,P均<0.05)。结论子痫前期的发生发展可能与Mimecan基因、NF-κB和IL-24有关。
Objective To investigate the expression and correlation of Mimecan gene, nuclear factor-κB (NF-κB) and interleukin-24 (IL-24) in preeclampsia (PE) Methods 98 cases of preeclampsia were divided into mild preeclampsia group (mild PE group, n = 53) and severe preeclampsia group (severe PE group, n = 45) according to the clinical manifestations of preeclampsia; 48 healthy pregnant women As a control group. The serum levels of Mimecan, NF-κB and IL-24 in pregnant women were detected by enzyme-linked immunosorbent assay (ELISA). Results The expression levels of Mimecan gene, NF-κB and IL-24 in preeclampsia group were (10.98 ± 0.82) mg / L and (21.97 ± 3.87) mg / L and (0.79 ± 0.26) mg / L respectively (4.78 ± 0.63) mg / L, (16.73 ± 4.31) mg / L and (0.38 ± 0.13) mg / L respectively, the differences were statistically significant (P <0.05) κB and IL-24 positively correlated with the severity of preeclampsia (r = 0.687, 0.733 and 0.821, respectively, P <0.05). Conclusion The occurrence and development of preeclampsia may be related to Mimecan gene, NF-κB and IL-24.