在某些情况下凋亡参与许多病理损伤。肿瘤坏死因子受体超家族(TNFRSF)中的死亡受体(DR)参与了细胞凋亡的过程,其中包括Fas(APO-1或CD95),TNFR I,DR3,DR4,DR5等。以往研究表明,Fas对于外周淋巴细胞的凋亡有重要的意义,而TNFRI除了可诱导凋亡外,还通过调节NF-κB和AP-1转录因子的基因表达,参与免疫细胞活化和炎症应答。DR4和DR5是两种以TRAIL为配体的死亡受体,与TRAIL结合后可引起细胞凋亡。 In some cases, apoptosis is involved in many pathological lesions. The death receptor (DR) in the tumor necrosis factor receptor superfamily (TNFRSF) is involved in the process of apoptosis, including Fas (APO-1 or CD95), TNFR I, DR3, DR4, DR5 and the like. Previous studies have shown that Fas has important significance for the apoptosis of peripheral lymphocytes. TNFRI not only induces apoptosis, but also regulates immune cell activation and inflammatory response by regulating the gene expression of NF-κB and AP-1 transcription factors. DR4 and DR5 are two death receptors that use TRAIL as a ligand. After binding to TRAIL, DRAIL can cause apoptosis.