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CD45分子是第一个被确认的典型的受体型蛋白酪氨酸磷酸酶α(receptor protein tyrosinephos phatase alpha,RPTPα),它几乎在所有的有核白细胞表面均有表达。利用CD45设门流式细胞仪检测可以实现白血病的快速、准确的诊断及免疫分型。抗CD45单抗的研制为白血病的靶向治疗提供新的手段。本文就CD45分子的结构及在白血病诊断和治疗中的应用及其前景进行阐述。
CD45 is the first confirmed receptor protein tyrosinephos phatase alpha (RPTPα), which is expressed on almost all nucleated leukocytes. The use of CD45 set door flow cytometry can achieve rapid and accurate diagnosis of leukemia and immunophenotyping. The development of anti-CD45 monoclonal antibody provides a new method for the targeted therapy of leukemia. This article describes the molecular structure of CD45 and its application in the diagnosis and treatment of leukemia and its prospects.