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1989年7月27日到29日在Mainz六届补体遗传会议及在柏林免疫学会议上,来自23个国家的一个遗传学小组成员对Ⅲ类MHC基因及补体多态现象的复杂性进行了讨论.Ⅲ类基因不仅包括补体,还有其它座位,如肿瘤坏死因子(TNF)α及β、21羟化(?)(21—OH)A及B、热休克蛋白70(HSP70)的重复基因,它们并无功能的相关性。除此之外,补体基因座位也见于染色体1(H,C4BP,CR1,C8A和B)染色体9(C8G)及染色体19(C3)。可能由于发生学、缺乏症及疾病等方面的原因,与MHC连锁的补体基因仍然吸引着众多人的重视.这些研究已成为中性论者(J.Klein,Tubingen)与选择论者(T.M(?)o,巴黎)思考的主题.
The complexity of class III MHC genes and complement polymorphisms was discussed by a panel of geneticists from 23 countries at the Mainz Sixth Complement Genetics Conference and at the Berlin Immunology Conference from July 27 to July 29, 1989 Class III genes include not only complement but also other loci such as tumor necrosis factor alpha and beta, 21-OH (21-OH) A and B, and heat shock protein 70 (HSP70) They have no functional relevance. In addition, complement loci are also found on chromosomes 1 (H, C4BP, CR1, C8A and B) on chromosome 9 (C8G) and on chromosome 19 (C3). Complementarity with the MHC is still attracting the attention of many people, probably due to the occurrence of learning, deficiency and disease, etc. These researches have been made by J. Klein, Tubingen and TM ?) o, Paris) The theme of thinking.