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引言致敏淋巴细胞和抗原接触时能释出淋巴因子,使巨噬细胞或白细胞的游走受到抑制。这现象最早为Rich和Lewis(1932)所发现。1962年George 和Vanghan建立了细胞游走抑制试验的毛细管法,成为研究细胞免疫的一个新方法。一般认为这方法和迟发性过敏反应比较相符(Thor等,1968;Rosenberg和David,1970;Ramsey等,1976),可用于检测淋巴细胞对抗原的致敏性和效应反应。目前已应用于细胞免疫和肿瘤免疫方面。方法学上有巨噬细胞游走抑制试验(Macrophage mi-gration inhibition test,MMIT)和白细胞
INTRODUCTION Sensitized lymphocytes can release lymphokines when in contact with antigens, inhibiting the migration of macrophages or leukocytes. This phenomenon was first discovered by Rich and Lewis (1932). In 1962, George and Vanghan established a capillary method for cell migration inhibition test, which became a new method to study cellular immunity. It is generally accepted that this method is consistent with the delayed-onset hypersensitivity response (Thor et al., 1968; Rosenberg and David, 1970; Ramsey et al., 1976) for detection of sensitization and response of lymphocytes to antigens. Has been used in cellular immunity and tumor immunity. Methodological macrophage migration inhibition test (Macrophage mi-gration inhibition test, MMIT) and leukocytes