目的 :研究鼻咽癌巨噬细胞的浸润与细胞分化和转移的关系。方法 :对 4 8例鼻咽癌(NPC)标本应用 (溶菌酶 )抗体以免疫组化技术标记NPC组织中巨噬细胞进行观察 ,同时进行了DNA含量及肿瘤转移率的测定和分析。结果 :首次发现不同DNA含量与NPC转移率之间存在显著性差异。二倍体巨噬细胞均数最高为 16 .3,高分化癌占 77.8% ,无一例发生淋巴结转移。四倍体肿瘤巨噬细胞均数降至 14.3,高分化癌占 4 0 % (8/ 2 0 ) ,且 6 5 %的标本发生了肿瘤的转移。非整倍体和异倍体肿瘤平均计数分别为 13.1%和 9.1%之间。结论 :这种依DNA含量分组揭示的巨噬细胞分布状况与肿瘤转移率间的规律性变化 ,可为临床和基础研究提供新途径。 Objective: To investigate the relationship between macrophage infiltration and cell differentiation and metastasis in nasopharyngeal carcinoma. Methods: Immunohistochemical technique was used to detect the macrophages in NPC tissues of 48 NPC specimens. The DNA content and tumor metastasis rate were measured and analyzed. Results: For the first time, there was a significant difference between different DNA content and NPC metastasis rate. The average number of diploid macrophages was 16.3, with high differentiated carcinoma accounting for 77.8%, and none of them had lymph node metastasis. The average number of tetraploid tumor macrophages decreased to 14.3, 40% of well-differentiated tumors (8/20), and 65% of the specimens had tumor metastasis. The average aneuploidy and aneuploid tumors were between 13.1% and 9.1%, respectively. Conclusion: The regular changes of the distribution of macrophages and the metastasis rate of macrophages revealed by DNA content group may provide a new way for clinical and basic research.