论文部分内容阅读
目的探讨外周血动静脉同步换血疗法在重症新生儿高胆红素血症中的效果评价与安全,以及采用本方法对机体血液内环境的影响。方法 2014年1月至2016年6月32例经外周动静脉同步换血治疗的高胆红素血症新生儿,检测换血术前与术后的血清胆红素水平、血糖、电解质、血常规及凝血功能,并进行分析比较。结果与换血前比较,治疗后的血清总胆红素、直接胆红素、间接胆红素均明显下降;白细胞和血小板减少,血钾降低,血糖有一定程度的升高,换血治疗前后差异有统计学意义(P<0.05)。血红蛋白轻微下降,血钙、血钠水平及凝血功能没有明显变化,换血治疗前后比较差异未见统计学意义(P>0.05)。结论换血疗法能有效降低新生儿高胆红素血症患儿血清胆红素水平,治疗效果显著,但短时间内可引起新生儿血液内环境的不同程度的变化,术后应密切观察内环境变化,以便及时处理。
Objective To investigate the effect evaluation and safety of peripheral blood and arterial venous transfusion therapy in severe neonatal hyperbilirubinemia and its influence on the blood environment of the body by this method. Methods From January 2014 to June 2016, 32 neonates with hyperbilirubinaemia treated by exchanging peripheral arterial and venous blood simultaneously were enrolled in this study. Serum bilirubin, blood glucose, electrolytes, blood and Blood coagulation, and analysis and comparison. Results Compared with before transfusions, serum total bilirubin, direct bilirubin and indirect bilirubin were significantly decreased after treatment; leucocyte and thrombocytopenia were decreased, serum potassium was decreased and blood glucose was increased to a certain extent; Statistical significance (P <0.05). Hemoglobin slightly decreased, serum calcium, serum sodium levels and coagulation function did not change significantly, before and after transfusion of blood treatment was no significant difference (P> 0.05). Conclusion The blood transfusion therapy can effectively reduce the serum bilirubin level in neonates with hyperbilirubinemia, and the treatment effect is significant. However, the changes of the blood environment in neonates may be caused in a short period of time. The internal environment should be observed closely Change for timely processing.