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目的探讨奥美拉唑治疗小儿消化道出血的临床疗效。方法选取宝鸡市妇幼保健院儿童医院2013年3月至2015年3月收治的100例小儿消化道出血患儿作为研究对象,随机分为对照组和观察组,每组患儿50例。两组患儿均给予支持、补液治疗。对照组患儿给予西咪替丁治疗,观察组患儿给予奥美拉唑治疗,对比治疗后两组患儿的临床疗效和不良反应。结果观察组患儿止血时间、住院时间和腹部不适症状消失时间分别为(1.02±0.49)、(4.78±1.53)和(1.02±0.31)d,均显著短于对照组的(2.48±1.31)、(7.15±1.62)和(2.05±1.15)d,差异有统计学意义(P1=0.002,P2=0.001,P3=0.000)。观察组患儿治疗总有效率为92%,高于对照组的74%,差异有统计学意义(P4=0.006)。治疗期间无不良反应出现。结论奥美拉唑用于治疗小儿消化道出血的临床疗效显著,值得推广使用。
Objective To investigate the clinical efficacy of omeprazole in the treatment of children with gastrointestinal bleeding. Methods A total of 100 pediatric patients with gastrointestinal bleeding admitted from March 2013 to March 2015 in Baoji Maternal and Child Health Hospital Children’s Hospital were randomly divided into control group and observation group with 50 cases in each group. Two groups of children were given support, fluid treatment. Children in the control group were treated with cimetidine, while those in the observation group were treated with omeprazole. The clinical efficacy and adverse reactions of the two groups were compared. Results The disappearance time of hemostasis, hospital stay and abdominal discomfort in the observation group were (1.02 ± 0.49), (4.78 ± 1.53) and (1.02 ± 0.31) days, respectively, which were significantly shorter than that of the control group (2.48 ± 1.31) (7.15 ± 1.62) and (2.05 ± 1.15) d, respectively. The difference was statistically significant (P1 = 0.002, P2 = 0.001, P3 = 0.000). The total effective rate of treatment group was 92%, which was higher than that of control group (74%), the difference was statistically significant (P = 0.006). No adverse reactions occurred during treatment. Conclusion Omeprazole has significant clinical efficacy in the treatment of children with gastrointestinal bleeding and is worth promoting.